Prenatal Exposure to Emerging Contaminants and Children's Atopic Dermatitis (PECCAD)

Fudan University

Status: Active, not recruiting

Conditions: Atopic Dermatitis

Treatments: Other: Gestational Exposure to Emerging Contaminants (ECs)

Study type: Observational

Funder types: Other

Identifiers

NCT06316609

AD2016-2027

Details and patient eligibility

About

This prospective cohort study aims to investigate the association between prenatal blood levels of Emerging Contaminants and the five-year incidence of atopic dermatitis (AD) in offspring.

Full description

This prospective birth cohort study, conducted within the Shanghai prenatal population, involves the collection of maternal blood samples during gestation to directly measure the biological exposure levels of Emerging Contaminants, including Per- and Polyfluoroalkyl Substances (PFAS), Organophosphate Flame Retardants (OPFRs), and Microplastics. Serum and whole blood levels of these contaminants are evaluated during pregnancy at 12-14, 22-26, and 31-34 gestational weeks. Subsequently, the study assesses skin barrier function in infants at 24-48 hours, 42 days, and 6 months of age. During a five-year period, the occurrence of atopic dermatitis (AD) in offspring is assessed. The objectives of this cohort study are twofold: (1) to elucidate the relationship between maternal exposure to Emerging Contaminants and the development of AD in offspring, and (2) to evaluate the impact of such exposure on the skin barrier function of infants. This research aims to provide substantial evidence for the prevention of AD, offering a unique and meaningful approach to mitigating the incidence of AD.

Enrollment: 456 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mother plans to proceed prenatal care and delivery in Minhang Maternal and Children Health Care Hospital
• 12-14 weeks of singleton pregnancy, non-stillborn or miscarrying, offspring without familial hereditary skin diseases
• Offspring plans to stay in Shanghai until 5 years and proceed follow-up at the Dermatology Department of Children's Hospital affiliated with Fudan University
• signed informed consent.

Exclusion criteria

• Multiple pregnancies
• perinatal death
• a fetus with congenital skin or appendages disorders

Trial design

456 participants in 2 patient groups

participants from birth cohort with AD

Description:

The association between maternal whole blood and serum levels of Emerging Contaminants (ECs) including Per- and Polyfluoroalkyl Substances (PFASs), Organophosphate Flame Retardants (OPFRs), and Microplastics during pregnancy and the incidence of atopic dermatitis in their offspring.

Treatment:

Other: Gestational Exposure to Emerging Contaminants (ECs)

participants from birth cohort without AD

Description:

The association between maternal whole blood and serum levels of Emerging Contaminants (ECs) including Per- and Polyfluoroalkyl Substances (PFASs), Organophosphate Flame Retardants (OPFRs), and Microplastics during pregnancy and the reduced incidence of atopic dermatitis in their offspring.

Treatment:

Other: Gestational Exposure to Emerging Contaminants (ECs)