Preoperative Administration of Lugols Solution in Toxic Thyroid Diseases (TD): A Prospective Study

Aristotle University Of Thessaloniki

Status: Active, not recruiting

Conditions: Toxic; Thyroid

Treatments: Dietary Supplement: Lugol's iodine solution 5%

Study type: Interventional

Funder types: Other

Identifiers

NCT06176976

LS trial

Details and patient eligibility

About

Lugol's solution and other preparations containing iodide have been used as an adjuvant treatment in patients with toxic disease planned for thyroidectomy. However, no conclusive evidence supporting the benefits of preoperative treatment with LS for patients with toxic goiters. This trial aims to provide new insights into future recommendations.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients ≥18 years of age
• Toxic thyroid disease, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy
• Written informed consent

Exclusion criteria

• prior thyroid or parathyroid surgery,
• hyperparathyroidism that requires associated parathyroidectomy,
• thyroid cancer that requires adding a lymph node dissection,
• iodine allergy,
• consumption of lithium or amiodarone,
• medically unfit patients (ASA-IV),
• breastfeeding women,
• preoperative vocal cord palsy and
• planned endoscopic, video-assisted or remote access surgery.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Thyroidectomy without lugols solution preparation

No Intervention group

Description:

euthyroid patients undergoing total thyroidectomy for toxic thyroid disease, no preoperative preparation with 5% lugols solution

Thyroidectomy with lugols solution preparation

Experimental group

Description:

euthyroid patients undergoing total thyroidectomy for toxic thyroid disease, preoperative preparation with 5% lugols solution for 10 days

Treatment:

Dietary Supplement: Lugol's iodine solution 5%