Preoperative and Postoperative Sublingual Misoprostol for Prevention of Postpartum Blood Loss in Cesarean Section

Assiut University

Status and phase: Completed; Phase 4

Conditions: Postpartum Hemorrhage

Treatments: Drug: Misoprostol

Study type: Interventional

Funder types: Other

Identifiers

NCT03591913

MISOCS

Details and patient eligibility

About

Cesarean section is one of the most common major surgical operations among women. In 2015, the incidence of cesarean section in Woman Health Hospital in Assiut University accounts for 51.3 % of all deliveries

Enrollment: 500 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• All pregnant women who will undergo elective lower segment cesarean section
• term ( ≥ 37 weeks)
• normal fetal heart tracing.

Exclusion criteria

• Placenta previa-Rupture uterus
• Classical cesarean section
• Preterm delivery
• Hypertensive disorders of pregnancy
• Bleeding tendency
• Previous history of postpartum hemorrhage
• Concurrent anticoagulant therapy
• Concurrent long-term use of steroids
• Fetal distress
• Antepartum haemorrhage

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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500 participants in 2 patient groups

study group

Experimental group

Description:

will receive sublingual misoprostol immediately after urinary catheterization and before skin incision

Treatment:

Drug: Misoprostol

control group

Active Comparator group

Description:

will receive sublingual misoprostol immediately after skin closure

Treatment:

Drug: Misoprostol