Preoperative Anxiety at Oocyte Retrieval

Trakya University

Status: Completed

Conditions: Anesthesia Awareness; Infertility, Female; Anxiety State

Treatments: Device: Monitoring brain function; Drug: propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03134651

TUTF-GOKAEK 2014/115

Details and patient eligibility

About

This study evaluated the effects of preoperative anxiety and dosage of anesthesia on IVF success. Half of participants according to the recorded Beck's Anxiety Inventory (BAI) score: a low-anxiety group, while the other half high-anxiety group.

Full description

Anxiety is common among women hospitalized for oocyte retrieval. Infertility is usually accompanied by psychological and behavioral changes and can result in preoperative anxiety. Sometimes, preoperative anxiety can be serious. Furthermore, in the absence of premedication for oocyte retrieval, severe degrees of anxiety may occur. Anxiety effects the total consumption of analgesic and anesthetic drugs intraoperatively and has a negative impact on recovery from anesthesia. In addition, the negative effect of anesthetic agents used on fertilization and embryo quality during in vitro fertilization (IVF) has been discussed. However, the impact of any of them on fertilization and embryo quality has not been clearly determined to date. Studies have reported different results regarding the negative effects of anesthetic agents on embryo development and fertilization.

Enrollment: 131 patients

Sex: Female

Ages: 25 to 43 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• oocyte retrieval under sedation
• 25 and 43 years of age
• American Society of Anesthesiologists physical status I-II

Exclusion criteria

• history of psychiatric illness
• secondary infertility can be surgically corrected
• not able to communicate well in the native language
• those women who necessitated general anesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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131 participants in 2 patient groups

Monitoring brain function-low-anxiety

Active Comparator group

Description:

Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.

Treatment:

Drug: propofol

Device: Monitoring brain function

monitoring brain function-high-anxiety

Active Comparator group

Description:

Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.

Treatment:

Drug: propofol

Device: Monitoring brain function