Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease

Luzerner Kantonsspital

Status: Unknown

Conditions: Aortic Valve Stenosis; Coronary Disease

Treatments: Other: DSCT, TTE

Study type: Interventional

Funder types: Other

Identifiers

NCT00767013

Cardiac imaging DSCT

Details and patient eligibility

About

We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Full description

Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

Enrollment: 65 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with aortic valve disease who were scheduled to undergo cardiac surgery

Exclusion criteria

• Hemodynamic instability
• Renal insufficiency (serum creatinine level > 133umol/L)
• Known allergy to iodinated contrast agents
• Non-treated hyperthyreosis

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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65 participants in 1 patient group

AVS, CAD

Experimental group

Description:

DSCT

Treatment:

Other: DSCT, TTE