Preoperative Biliary Drainage for Resectable Hilar Cholangiocarcinoma
Status and phase
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Study type
Funder types
Identifiers
Details and patient eligibility
About
This study is to investigate whether preoperative biliary drainage can reduce the postoperative morbidity in patients with hilar cholangiocarcinoma.
Full description
Preoperative biliary drainage(PBD) or not, is a Hot Spot issue in the management of Hilar cholangiocarcinoma. Surgeons from Japan tend to perform PTBD(Percutaneous Transhepatic Biliary Drainage) before a definite operation until the total bilirubin(TB) lower than 85μmol/L. For some patients needed to perform extended curative resection, PVE(Portal Vein Embolization) is performed and thus the duration of PBD may be around six weeks and the final TB is lower than 34μmol/L. Some tend to perform a definite curative operation in a short time after diagnosis. There is no RCT research on the effect of PBD for the resectable Hilar Cholangiocarcinoma patients to date.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Patients newly diagnosed
- Resectable patients after imaging assessment and evaluation of general condition of the patient
- TB>85μmol/L
- WBC account more than 1.5×109/L, PLT account more than 100×109/L and HB account more than 100g/L
- No serious disease in heart, lung and kidney
- Written informed consent
Exclusion criteria
- Unresectable patients.
- Patients have received biliary drainage procedure such as PTBD before admission
- Complicated with chronic hepatitis
- Myocardia infarction record within six months
- Women in pregnancy
- Serious disease in heart, lung or kidney
Trial design
Primary purpose
Allocation
Interventional model
Masking
82 participants in 2 patient groups
Trial contacts and locations
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Central trial contact
Lijian Liang
Data sourced from clinicaltrials.gov
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