Preoperative Estimation of Microvascular Invasion in Hepatocellular Carcinoma

Ming Kuang

Status: Unknown

Conditions: Hepatocellular Carcinoma

Treatments: Diagnostic Test: contrast-enhanced ultrasound; Diagnostic Test: contrast-enhanced computed tomography

Study type: Observational

Funder types: Other

Identifiers

NCT03110068

SYSU01-US-201701

Details and patient eligibility

About

Presence of microvascular invasion can be estimated preoperatively, by some clinical imaging features such as patient characteristics, serum biomarkers and radiological features. Contrast-enhanced ultrasonography (CEUS) and contrast-enhanced computed tomography (CECT) are routine preoperative conventional examinations for hepatocellular carcinoma (HCC) patients in China. Combining features of CEUS, CECT and clinical factors may improve preoperative MVI assessment. The purpose of this study is to construct a nomogram for preoperative MVI risk estimation with these possible factors.

Enrollment: 370 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asian patients aged 18～80 years old;
• With no preoperative anti-cancer treatment;
• Scheduled for radical liver resection;
• With both CEUS and CECT performed in 4 weeks before surgery;
• Postoperative histologically confirmed HCC;
• With sufficient surgical specimen for MVI detection (surgical margin ≥1cm);

Exclusion criteria

• Recurrent HCC or combined hepatocellular-cholangiocarcinoma;
• With extra-hepatic metastasis or macrovascular invasion;
• With incomplete clinical and imaging data;
• Non-radical resection;

Trial design

370 participants in 1 patient group

Preoperative clinical/imaging features

Description:

In this project, there is only one study group which comprises of patients with Hepatocellular Carcinoma (HCC) who will undergo contrast-enhanced computed tomography (CECT) and contrast-enhanced ultrasound (CEUS).

Treatment:

Diagnostic Test: contrast-enhanced ultrasound

Diagnostic Test: contrast-enhanced computed tomography