Preoperative Excercise Training for Patients Undergoing Coronary Artery Bypass Graft Surgery

Kerckhoff Klinik

Status: Completed

Conditions: Coronary Artery Bypass Graft Surgery; Coronary Artery Disease; Physical Activity

Treatments: Other: Optimal medical therapy; Other: Preoperative Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT04111744

PRECAB

Details and patient eligibility

About

Patients (pts) with stable coronary artery disease (CAD) requiring coronary artery bypass graft surgery (CABG) may be physically inactive during the waiting period to avoid further risks. Aim of this study is to investigate the feasibility and safety of a preoperative aerobic exercise training in these pts during the waiting period and to analyze its effects on pre-, peri and postoperative outcomes

Full description

Pts with stable coronary artery disease (CAD) and indication for elective CABG will be prospectively randomized into a preoperative training group (TG) or a non active control group (CG). Pts in TG have to perform six sessions of aerobic endurance training within two weeks prior to CABG. The following investigations will be performed at baseline, one day before surgery and at the beginning and at the end of cardiac rehabilitation: a maximal symptom limited ergospirometry, assessment of endothelial function (analysing the reactive hyperaemic index (RHI) via a finger-tonometry), assessment of quality of life (QoL) using the MacNew Heart Disease Questionnaire, laboratory testing of ischemic and inflammatory Parameters. Baseline, peri- and postoperative characteristics will be collected.

Enrollment: 203 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable Angina
• indication for elective CABG surgery
• functional capacity > 50 watts
• willingness to participate in the study

Exclusion criteria

• unstable Angina
• comorbidities precluding performance of aerobic exercise training (e.g. neurological disorders, orthopedic disorders etc)
• functional Status NYHA IV
• relevant ventricular arrhythmias
• hemodynamic significant heart valve disease
• myocarditis
• cardiomyopathies
• left main coronary artery disease > 50%
• peripheral obstructive disease (Fontaine > IIb)
• reduced life expectancy < 12 months
• CABG surgery during the last six months
• participation in another trial

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

203 participants in 2 patient groups

Training Group

Experimental group

Description:

Preoperative Exercise Training Optimal medical therapy,

Treatment:

Other: Preoperative Exercise Training

Other: Optimal medical therapy

Control Group

Other group

Description:

Optimal medical therapy, inactive control group

Treatment:

Other: Optimal medical therapy