Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery

Samsun University

Status: Enrolling

Conditions: Emergency Surgery; Acute Kidney Injury; Hemoglobin

Treatments: Other: Observational

Study type: Observational

Funder types: Other

Identifiers

NCT06857630

GOKAEK 2024/19/4

Details and patient eligibility

About

Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood transfusion or various interventions to increase hemoglobin levels on outcomes continue to be debated. The effects of hemoglobin levels in emergency surgery patients on the development of postoperative AKI have been investigated in a small number of studies in the literature, and clear results have not yet been reported. This study was designed to evaluate the effect of hemoglobin levels on the development of AKI after adjustment for known predictive factors.

Full description

Acute kidney injury (AKI) is a common complication in patients undergoing major surgery and is associated with both short-term morbidity and mortality and long-term adverse outcomes including the development of Chronic Kidney Failure. Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of various interventions such as blood transfusion or increasing hemoglobin levels on outcomes continue to be debated. This prospective observational study was planned to evaluate the effect of hemoglobin levels before emergency surgery on the development of postoperative AKI.

Emergency operated patients will be divided into two groups as Group AKI and Group non-AKI according to the development of postoperative renal failure. Postoperative AKI diagnosis and severity will be evaluated according to serum creatinine and/or urine output according to KDIGO (Kidney Disease: Improving Global Outcomes criteria).

Demographic characteristics of the patients, preoperative complete blood count, blood biochemistry characteristics, hemodynamic variables, fluid replacement, blood and blood product replacements, surgical characteristics, development and severity of AKI in the postoperative period will be recorded and the effect of hemoglobin level on the development of AKI will be evaluated.

Enrollment: 420 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing emergency non-cardiac surgery

Exclusion criteria

• Known renal failure
• Need for reoperation within 48 hours postoperatively
• Exit status within 48 hours postoperatively
• Known hematological disease
• Known kidney transplantation
• Urgent surgery planned due to urinary system related diseases
• Patients who did not accept to participate in the study

Trial design

420 participants in 2 patient groups

Group AKI

Description:

Postoperative renal failure

Treatment:

Other: Observational

Group non-AKI

Description:

Postoperative non renal failure

Treatment:

Other: Observational