Preoperative Hepatic Arterial Infusion Chemotherapy

San Donato Group (GSD)

Status: Unknown

Conditions: Colorectal Liver Metastases

Treatments: Drug: Floxuridine FUDR

Study type: Observational

Funder types: Other

Identifiers

NCT00522509

Neoadjuvant HAIC

Details and patient eligibility

About

To assess the feasibility and results of liver resection after preoperative hepatic artery infusion (HAI) chemotherapy with FUDR.

Full description

Between 1995 and 2004, 239 patients with isolated colorectal liver metastases received HAI chemotherapy with neoadjuvant intent. Fifty of these patients underwent subsequent curative liver resection (HAI group).

Postoperative morbidity, liver function tests, and long term outcomes were evaluated. Adverse events related to HAI chemotherapy were also evaluated.

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Unresectable liver metastases
• Potentially resectable liver metastases

Exclusion criteria

• Extrahepatic disease