Preoperative Imaging in Retroperitoneal Sarcoma (PIRS)

Institute of Cancer Research, United Kingdom

Status: Completed

Conditions: Cancer

Treatments: Procedure: Magnetic Resonance Imaging

Study type: Observational

Funder types: Other

Identifiers

NCT01902667

13/EE/0186 CCR3992

Details and patient eligibility

About

This is a prospective observational study in which patients with untreated retroperitoneal sarcoma will have Magnetic Resonance Imaging (MRI) prior to surgery. In addition, patients who will be undergoing pre-operative radiotherapy will have an additional MRI scan at two weeks post radiotherapy. For both groups, the magnetic resonance images will be correlated with tumour pathology.

The study hypothesis is that Magnetic Resonance Imaging will provide a more accurate assessment of tumour volume and local staging than CT and will identify areas of altered oxygenation, cellularity and perfusion which change in response to radiotherapy before tumour shrinkage occurs.

Enrollment: 32 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with retroperitoneal sarcomas planned for surgical resection +/- preoperative radiotherapy.

Exclusion criteria

• MRI incompatible metal implants
• claustrophobia

Trial design

32 participants in 2 patient groups

Curative intent surgery alone

Description:

Patients with retroperitoneal sarcoma randomised into surgery alone arm.

Treatment:

Procedure: Magnetic Resonance Imaging

Pre-operative radiotherapy plus surgery

Description:

Patients with retroperitoneal sarcoma randomised to Arm 2: pre-operative radiotherapy plus surgery.

Treatment:

Procedure: Magnetic Resonance Imaging