Preoperative Immunonutrition in Laparoscopic Total D2 Gastrectomy

University of Rome Tor Vergata

Status: Completed

Conditions: Gastric Cancer; Gastric Neoplasm; Surgery; Digestive Cancer; Laparoscopic

Treatments: Dietary Supplement: immunonutrition

Study type: Observational

Funder types: Other

Identifiers

NCT05259488

Protocollo xx/22

Details and patient eligibility

About

Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery. More specifically, it seems to be beneficial also in gastric cancer surgery. Potential benefits of combining preoperative IN (PIN) with protocols of enhanced recovery after surgery (ERAS) in reducing LOS in laparoscopic total gastrectomy are yet to be determined.

Enrollment: 51 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years
• Primary gastric cancer
• Preoperative staging I-III
• Eligible for laparoscopic D2 total gastrectomy

Exclusion criteria

• Acquired or congenital immunodeficiency
• Malnutrition (MNA-SF score < 12)
• Preoperative infection
• Previous gastric surgery
• ASA IV
• Emergency setting
• Para-aortic node involvement
• Intraoperative evidence of distant metastasis or peritoneal carcinosis
• Conversion to open surgery

Trial design

51 participants in 2 patient groups

patients receiving immunonutrition supply

Description:

Dietary Supplement: Immunonutrition nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery

Treatment:

Dietary Supplement: immunonutrition

historical control group

Description:

standard dietary advice