Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

Ain Shams University

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Diagnostic Test: increase in serum creatinine

Study type: Observational

Funder types: Other

Identifiers

NCT05390281

FMASU MD 368/2018

Details and patient eligibility

About

Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

Enrollment: 40 patients

Sex: All

Ages: 45 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status II-III
• scheduled to undergo isolated coronary artery bypass grafting

Exclusion criteria

• Patients with history of renal failure
• Patients with history of hepatic failure
• Patients with history of heart failure
• previous cardiac surgery
• cerebrovascular event in the last 30 days
• percutaneous coronary intervention in the last 30 days prior to operation
• peripheral arterial disease
• malignancy
• infectious diseases
• patients who required surgical revision
• patients who required postoperative intra-aortic balloon pump
• patients with CBP time > 120 min or aortic cross clamp time > 90 min

Trial design

40 participants in 2 patient groups

Pre-diabetic group

Description:

Patients with preoperative HbA1c 5.7-6.4% (group A) (prediabetics)

Treatment:

Diagnostic Test: increase in serum creatinine

Diabetic group

Description:

Patients with preoperative HbA1c \> or = 6.5% till 7% or \> 7% in case of emergency surgery or rapidly progressive cases with no time for long-term glycemic control (group B) (diabetics)

Treatment:

Diagnostic Test: increase in serum creatinine