Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer

Hacettepe University

Status: Completed

Conditions: Colorectal Cancer

Treatments: Diagnostic Test: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30); Diagnostic Test: Prognostic Nutritional Index (PNI); Diagnostic Test: Dietary inflammatory index (DII); Diagnostic Test: Neutrophil-Lymphocyte Ratio (NLR); Diagnostic Test: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal Cancer 29 (EORTC-QLQ-CR29); Diagnostic Test: Global Leadership Initiative on Malnutrition (GLIM); Diagnostic Test: Nutrition Risk Screening 2002 (NRS-2002); Other: Measurement of body composition with computed tomography (CT)

Study type: Observational

Funder types: Other

Identifiers

NCT06016829

GO 21/499

Details and patient eligibility

About

The aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes. The study will include 120 colorectal cancer patients who are scheduled for surgical treatment.

Full description

A questionnaire form containing general information, dietary habits, and food consumption records will be applied by the researcher in the preoperative period to the patients who volunteered to participate in the study. Body composition will be taken by bioelectrical impedance analysis method. Hand grip strength will be taken with a digital hand dynamometer. The nutritional status of patients will be assessed using the criteria of the Nutritional Risk Screening 2002 (NRS-2002) and the Global Leadership Initiative on Malnutrition (GLIM). For body composition analysis, computed tomography images, known as the gold standard, will be used in cancer patients. Computed tomography images of the patients will be obtained from hospital records at L3 lumbar vertebra level. The software program ImageJ developed by the US National Institute of Health will be used to calculate the visceral fat area (cm2), subcutaneous fat area (cm2), and skeletal muscle area (cm2) from the recorded images.

Preoperative biochemical parameters will be obtained from hospital records. The systemic inflammatory response will be determined by the Prognostic Nutritional Index, Neutrophil Lymphocyte Ratio, and Delta Neutrophil Index. The inflammatory load of the diet will be calculated using the Dietary Inflammatory Index. The quality of life of patients will be assessed using cancer-specific scales developed by the European Organisation for Research and Treatment of Cancer (EORTC) during the preoperative and postoperative periods. These scales are EORTC-QLQ-C30 for general quality of life and EORTC-QLQ-CR29 for colorectal cancer-specific quality of life.

Enrollment: 121 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Having been diagnosed with colorectal cancer and having surgical treatment planned
• Being 18 years of age or older

Exclusion criteria

• Having received chemotherapy or radiotherapy
• Currently undergoing corticosteroid or hormone treatment.
• Presence of distant metastases.
• Presence of any malignancy other than colorectal cancer.
• Presence of autoimmune disease.
• Presence of ongoing infectious disease.