Preoperative Oral Carbohydrate Treatment Minimizes Insulin Resistance

The Second Affiliated Hospital of Dalian Medical University

Status: Unknown

Conditions: Insulin Resistance

Treatments: Dietary Supplement: Preoperative Oral Carbohydrate Drink

Study type: Interventional

Funder types: Other

Identifiers

NCT03658564

poster2017

Details and patient eligibility

About

Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Full description

Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Enrollment: 80 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery

Exclusion criteria

• Weight loss greater than 10 per cent during the previous 6 months
• Renal insufficiency (creatinine, > 3 mg/dl; hemodialysis)
• Hepatic insufficiency (Child-Pugh class, ≥ B)
• Gastro-oesophageal reflux disease
• Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Oral carbohydrate

Experimental group

Description:

fast from midnight the night before surgery, and patients consume 400 ml Preoperative oral carbohydrate preOp®(12.5% carbohydrates, 0.5%kcal/ml, 240 mOsm, pH 4.9, Nutricia Zoetermeer, the Netherlands) 3 hours prior to induction of anesthesia and finished the ingestion within 20 minutes.

Treatment:

Dietary Supplement: Preoperative Oral Carbohydrate Drink

Fasting

No Intervention group

Description:

fast from midnight the night before surgery, and no preoperative oral carbohydrate loading