Preoperative Renal Insufficiency Predicts Postoperative Adverse Outcomes

Taipei Medical University

Status: Completed

Conditions: Morality; Renal Insufficiency

Treatments: Diagnostic Test: estimated GFR calculation

Study type: Observational

Funder types: Other

Identifiers

NCT05455528

202206019

Details and patient eligibility

About

The main purpose of this study is to evaluate the risk of postoperative mortality and complications in surgical populations with preoperative renal insufficiency.

Full description

This retrospective cohort study use the National Surgical Quality Improvement Program (NSQIP) database to evaluate the risk of postoperative morbidity and mortality in the surgical population. Patients with estimated. glomerular filtration rate(GFR) < 60 ml/min per 1.73 square meter are defined as the renal insufficiency group. Patients with estimated GFR > 90 ml/min per 1.73 square meter are defined as patients without renal insufficiency. Propensity score-matching methods and multivariate logistic regression are used to calculate the risk of postoperative morbidity and mortality.

Enrollment: 2,421,286 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with estimated GFR < 60 ml/min per 1.73 square meter or currently on dialysis are included in renal insufficiency group.
• Patients with estimated GFR > 90 ml/min per 1.73 square meter are included in non-renal insufficiency group

Exclusion criteria

• Patients population with estimated GFR between 60-90 is not included in the study

Trial design

2,421,286 participants in 2 patient groups

renal insufficiency group

Description:

1. Surgical population currently on dialysis 2. Surgical population with estimated GFR \< 60 ml/min per 1.73 square meter within 90days before the index surgery. The estimated GFR

Treatment:

Diagnostic Test: estimated GFR calculation

Non-renal insufficiency group

Description:

Defined as the study subjects with eGFR \> 90 60 ml/min per 1.73 square meter within 90 days before the index surgery

Treatment:

Diagnostic Test: estimated GFR calculation