Preoperative Serum FGF19 in the Prognosis of Biliary Atresia

Fudan University

Status: Enrolling

Conditions: Prognosis; Biliary Atresia

Study type: Observational

Funder types: Other

Identifiers

NCT05848310

SFPBA

Details and patient eligibility

About

To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.

Full description

Kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. Accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. Serum FGF19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in Asian population, thus the investigators try to further explore the prognostic value of serum FGF19 in children with biliary atresia based on a large sample.

Enrollment: 200 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Samples diagnosed as biliary atresia in Children's Hospital of Fudan University
• Samples with one-year follow-up records after surgery
• Samples with a record of serum total bilirubin levels three months after surgery
• Samples with preoperative serum left（volume > 500ul)

Exclusion criteria

• None

Trial design

200 participants in 1 patient group

Good prognosis + Poor prognosis

Description:

Good prognosis: the serum total bilirubin level was less than 20 umol/l three months after surgery, and no liver transplantation or death occurred within a year after surgery. Poor prognosis: the serum total bilirubin level was higher than 20 umol/l three months after surgery, and no liver transplantation or death occurred within a year after surgery.