Preoperative Single Glucocorticoid Hip Fracture Hip Fracture Surgery

Hvidovre University Hospital

Status and phase

Completed

Phase 4

Conditions

Delirium - Postoperative

Stress, Physiological

Treatments

Drug: placebo saline

Drug: methylprednisolone sodium succinate

Study type

Interventional

Funder types

Other

Identifiers

NCT02317601

2014-002492-29 (EudraCT Number)

Details and patient eligibility

About

The Study is a double-blinded, randomized, placebo-controlled trials. The Objective is to investigate the effect of single-high-dose glucocorticoid on surgical stress response and postoperative delirium among Elderly hip Fracture Patients undergoing surgery.

Full description

Patients with Hip Fracture are exposed for two traumas that can trigger a stress response. The first is the fall that causes the Fracture. The second is the surgery. In this study the intervention is dispensed early in the disease course - as soon as the Fracture has been diagnosed and booked for surgery.

Enrollment

122 patients

Sex

All

Ages

65+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients undergoing surgery for hip fracture
Informed signed consent
Danish speaking

Exclusion criteria

Allergies towards contents of Solu-Medrol
Insulin dependent diabetes
Glaucoma
In treatment for cancer disease
Positive HIV, Hepatitis b or C status
Lack of informed consent (eq. Severe dementia, coma, and others)
Current treatment with systemic glucocorticoids (pr.os or intravenous) Immunoinflammatory disease (Except topical treated skin disease and respiratory disease)
Current Immunosuppressive treatment
Unable to participate in CAM-S measurement
Peptic ulcera