Preopioid Versus Nonopioid in Total Knee Arthroplasty (TKA)

Hvidovre University Hospital

Status: Completed

Conditions: Postoperative Pain

Study type: Observational

Funder types: Other

Identifiers

NCT01323179

11123111

Details and patient eligibility

About

Observational study evaluating pain response after total knee arthroplasty (TKA) in patients taking strong, weak or no opioids preoperatively.

Enrollment: 140 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients operated with elective, primary, unilateral total knee arthroplasty (TKA) (taking strong or weak opioid daily for minimum 4 weeks or opioid naive patients)

Exclusion criteria

• Bilateral / revision arthroplasty
• Disease affection central or peripheral nerve function
• Alcohol and medical abuse
• Daily use of glucocorticoids
• Malignancy
• BMI > 40
• Dementia or other cognitive dysfunction
• Treatment of anxiety or depression

Trial design

140 participants in 3 patient groups

Strong opioids

Description:

Patients taking strong opioids preoperatively

Weak opioids

Description:

Patients taking weak opioids preoperatively

Opioid native

Description:

Patients not taking opioids preoperatively