Preoxygenation With High Flow Nasal Cannula Prolongs Normoxia Time During Induction of Anaesthesia of Bariatric Patients and is Superior to Conventional Preoxygenation With Face Mask.

Staedtisches Klinikum Karlsruhe

Status: Unknown

Conditions: Compare Preoxygenation Methods in Bariatric Patients

Treatments: Other: Preoxygenation via face mask; Other: Preoxygenation with High Flow Nasal Cannula

Study type: Interventional

Funder types: Other

Identifiers

NCT04965610

070720211

Details and patient eligibility

About

To compare preoxygenation for induction of general anaesthesia with High Flow Nasal Cannula vs preoxygenation with face mask in patients undergoing bariatric surgery. The hypothesis is that preoxygenation with High Flow Nasal Cannula prolongs normoxia time during induction of anaeshesia and is superior to conventional preoxygenation with face mask. Primary endpoint will be the time during which spO2 > 92 %. Secondary endpoint will be paCO2.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age over 18
• elective bariatric surgery
• written consent

Exclusion criteria

• preexisting lung diseases, congenital heart diseases
• known difficult airway
• SpO2 < 92% under ambient air conditions
• known diaphragmal hernia
• clinically relevant reflux

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Preoxygenation via THRIVE/High Flow Nasal Cannula

Experimental group

Description:

Patients receive preoxygenation for induction of general anaesthesia via High Flow Nasal Cannula for the duration of 5 minutes. After that the induction agents will be given. Now arterial blood gases will be drawn every 2 minutes and the SpO2 will be measured until the 6th apnoeic ABG or if the SpO2 decreases to 92%. After that normal intubation follows.

Treatment:

Other: Preoxygenation with High Flow Nasal Cannula

Preoxygenation via face mask (PROX)

Active Comparator group

Description:

Patients receive preoxygenation for induction of general anaesthesia via tight fitting face mask for the duration of 5 minutes. After that the induction agents will be given. Now arterial blood gases will be drawn every 2 minutes and the SpO2 will be measured until the 6th apnoeic ABG or if the SpO2 decreases to 92%. After that normal intubation follows.

Treatment:

Other: Preoxygenation via face mask