Status and phase
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About
The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.
Full description
Prescription opioid abuse is becoming an increasingly widespread and serious public health concern. The 2001 National Household Survey on Drug Abuse report revealed that the number of first-time users of prescription opioid medications for non-medical reasons reached 2 million in the year 2000, a number that has quintupled since 1984. Despite this trend, little experimental research has been directed towards understanding who may be abusing these medications, and under what conditions. The study will examine the reinforcing, subjective, performance, and physiological effects of oxycodone. Because it is not clear who is abusing prescription opioids, the medication effects will be compared in drug abusers and non-drug abusers.
Enrollment
Sex
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Volunteers
Inclusion criteria
Exclusion criteria
On parole or probation
Recently convicted of a crime of violence
History of significant violent behavior
Current Axis I psychopathology
Significant Axis II disorder
Pregnancy
Women who have irregular menstrual cycles, or who are dysmenorrheic, amenorrheic, or menopausal
Women who have been pregnant or breastfeeding within the past 6 months
Women who have had a miscarriage or abortion within the past 6 months
Women who meet DSM-IV criteria for premenstrual dysphoric disorder
Women who report suffering from moderate to severe premenstrual symptoms
Women seeking treatment for premenstrual problems
Taking prescription or over-the-counter psychotropic medication
History of chronic pain, or routinely uses over-the-counter analgesics (more than 4 days per month)
Blood pressure greater than 150/90 mm Hg
Reports of sensitivity, allergy, or contraindication to opioids
Non-drug abusers:
Primary purpose
Allocation
Interventional model
Masking
27 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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