Prescription Patterns of Antidepressants, Analgesics, and Antiepileptics Drugs in Adult With Acquired Brain Injury (PRES'SMR)

Caen University Hospital

Status: Completed

Conditions: Acquired Brain Injury Including Stroke

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT06983314

4726

Details and patient eligibility

About

Acquired brain injury (ABI), primarily caused by stroke and traumatic brain injury (TBI), leads to severe disabilities and requires complex pharmacological management during post-acute rehabilitation. The lack of dedicated guidelines and regular treatment re-evaluation increases the risk of adverse drug reactions (ADRs).

Retrospective, bicentric study in two rehabilitation centers in Normandy, France, from November 1, 2020, to October 31, 2023, to describe prescription patterns of antidepressants, antiepileptics, and analgesics, as well as potential drug-related complications.

Enrollment: 201 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults hospitalized in a rehabilitation center for acquired brain injury (ABI) after passing through an acute care department.
• ABI must be the primary diagnosis in the PMSI (French medical information system).
• The pharmacological classes of interest (antidepressants, antiepileptics, analgesics) must have been introduced during acute care or within the first month of hospitalization in the rehabilitation center.

Exclusion criteria

• Patients who did not receive new prescriptions for the pharmacological classes of interest during acute care or the first month of hospitalization in the rehabilitation center.
• Patients who were already prescribed these drugs prior to the ABI.
• Patients who were not hospitalized immediately after discharge from acute care (patients must have been transferred directly from acute care to the rehabilitation center, without spending time in another department or at home).
• Patients who were transferred to an emergency department during rehabilitation and did not return to the rehabilitation center.
• Patients who died during hospitalization or were discharged against medical advice.

Trial design

201 participants in 1 patient group

Group

Description:

Patients with Acquired Brain Injury (ABI) receiving prescribed antidepressants, antiepileptics, and analgesics during hospitalization.

Treatment:

Other: Observation