Presence of Nanoparticles in the Amniotic Fluid (NAMIOTIC)

Centre Hospitalier Universitaire de Saint Etienne

Status

Completed

Conditions

Intrauterine Disorder

Treatments

Procedure: Nanoparticles load

Study type

Observational

Funder types

Other

Identifiers

NCT02720887

2016-A00250-51 (Other Identifier)

1608016

Details and patient eligibility

About

The nanoparticles (NP) are defined as particles whose size is no greater than 100 nanometers. However, their impact on health remains little evaluated.

Placental transfer of NP has been proven in many studies in vitro and in vivo in animals, and toxicity in the fetus has been studied in many animals. The investigators seem interesting at first to establish the mineralogical load in the amniotic fluid in humans.

The first objective of this study is to determine the mineralogical NP load, quantity and composition, in the amniotic fluid in pregnant women.

Full description

The analysis will be done on 100 amniotic fluid samples and 100 blood samples. Particle size analysis will be performed by a technique of dynamic light scattering, which permits the distribution by volume or by number of NP according to their size. Parallel to the different chemical species present in the sample must be measured by atomic emission spectrometry with inductively coupled plasma.

The results of this study will be useful for further studies on the fetal toxicity of NP in humans.

Enrollment

95 patients

Sex

Female

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient major
Patient to receive an amniocentesis for medical reasons other than study (serum marker of the first quarter with an increased risk of trisomy 21 greater than 1/250, amniodrainage, sonographic sign of call)
Patient who have given their free, informed and signed

Exclusion criteria