Preservation of Inferior Mesenteric Artery Could Improve Sexual Function After Laparoscopic Colorectal Resection for Diverticular Disease (IMAPSEX)

University of Roma La Sapienza

Status: Completed

Conditions: Sexual Function Disturbances

Treatments: Procedure: Inferior Mesenteric Artery Preservation; Procedure: Inferior Mesenteric Artery Ligation

Study type: Interventional

Funder types: Other

Identifiers

NCT04752241

DS-041

Details and patient eligibility

About

This study aims to evaluate whether IMA sparing may represent an advantage in terms of reduced incidence and severity of sexual dysfunctions after colorectal resections for diverticular disease (DD).

Full description

Enrolled patients were randomly divided into 2 treatment groups. In the first group (IMAP) the IMA was preserved sectioning the sigmoid arteries near colonic wall while, in the second group (IMAS) the IMA was sectioned immediately below the origin of the left colic artery. Incidence and severity of sexual dysfunction and QoL were assessed by four validated questionnaire administered 6,12 months and 5 and 8 years after surgery.

Enrollment: 300 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diverticular disease
• Diverticulitis
• BMI under 35 Kg/mq
• ASA score from I to III
• Standardized sigmoid, left colon or rectal resection

Exclusion criteria

• complicated diverticulitis (Hinchey III-IV)
• previous abdominal surgery or prostatic and/or gynecological resections
• adverse local condition or the need of multiorgan resection or stoma creation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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300 participants in 2 patient groups

IMAP

Experimental group

Description:

Inferior Mesenteric Artery Preservation Performing left hemicolectomy and anterior rectal resection the IMA was preserved ligating close to the colonic wall the sigmoids arteries.

Treatment:

Procedure: Inferior Mesenteric Artery Preservation

IMAS

Active Comparator group

Description:

Inferior Mesenteric Artery Ligation Performing left hemicolectomy the IMA is ligated and sectioned after the origin of left colic artery

Treatment:

Procedure: Inferior Mesenteric Artery Ligation