Preservative-Free MK2452 (Tafluprost) for Open-Angle Glaucoma/Ocular Hypertension (MK2452-001)(COMPLETED)

Merck Sharp & Dohme (MSD) logo

Merck Sharp & Dohme (MSD)

Status and phase

Phase 3


Open-angle Glaucoma
Ocular Hypertension


Drug: Preservative-Free Tafluprost
Drug: Comparator: timolol

Study type


Funder types




Details and patient eligibility


This study was to compare the safety and efficacy of the preservative-free formulation of 0.0015% MK2452 (tafluprost) and preservative-free 0.5% timolol maleate in patients with open-angle glaucoma and ocular hypertension. This study was to demonstrate that the preservative-free formulation of 0.0015% tafluprost is non-inferior to preservative-free 0.5% timolol maleate.


643 patients




18+ years old


No Healthy Volunteers

Inclusion criteria

  • Patient has been diagnosed with primary open-angle glaucoma, pigmentary glaucoma, capsular glaucoma/pseudoexfoliation, or ocular hypertension
  • Patient has a mean (or median) IOP of >=23 and =<36 in at least one eye at the 0800 hours time point at the Baseline Visit.
  • Patient has <5 mmHg difference in mean (or median) IOP between eyes at each time point (0800 hours, 1000 hours, and 1600 hours) at Baseline.
  • Patient is currently using a prescribed ocular hypotensive medication and has been on a stable dose for 30 days prior to screening, or patient is drug-naive (those who have never used or who have not used ocular hypotensive medication for at least 4 weeks prior to screening)
  • Patient is able to safely discontinue current ocular hypotensive medication during up to the 4-week washout period
  • Patient has vision corrected to 20/80 or better in each eye
  • Patient is willing and able to avoid wearing contact lenses from 4 weeks prior to dosing through 24 hour after final dosing
  • Patient is willing and able to self-administer or has an able person available on a daily basis to assist with administration of study medications
  • Patient is not pregnant and not planning to become pregnant during the study
  • Patient is male or female ≥18 of age on the day of signing the informed consent

Exclusion criteria

  • Patient is unable to use study medication in the affected eye(s)
  • Patient has a history of inflammatory ocular surface disease or anterior or posterior uveitis in either eye
  • Patient has a history of retinal detachment, diabetic retinopathy, or other progressive retinal disease
  • Patient has experienced significant visual field loss within the last year
  • Patient has had intraocular surgery in either eye in the last 4 months
  • Patient has a history of glaucoma surgery or refractive surgery in either eye
  • Patient is currently taking two or more anti-glaucoma medications (except Cosopt™ or its generic formulation)
  • Patient has previously used tafluprost
  • Patient has a history of cardiovascular disorder within 6 months prior to screening
  • Patient has a history of bronchial asthma, wheezing, pneumonia, COPD, other pulmonary disease, or abnormal chest x-ray
  • Patient has a mean (or median) IOP >36 mmHg in either eye at the Screening Visit or at any time point (0800 hours, 1000 hours, and 1600 hours) of the Baseline Visit.

Trial design

Primary purpose




Interventional model

Parallel Assignment


Double Blind

643 participants in 2 patient groups

Experimental group
Preservative-free tafluprost
Drug: Preservative-Free Tafluprost
timolol maleate
Active Comparator group
Preservative-free timolol maleate
Drug: Comparator: timolol

Trial contacts and locations



Data sourced from

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