Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial (SBT-ICU)

Civil Hospices of Lyon

Status: Completed

Conditions: Critically Ill Adult Patients With Difficult Weaning

Treatments: Procedure: Non assisted strategy; Procedure: Assisted strategy

Study type: Interventional

Funder types: Other

Identifiers

NCT03861117

69HCL18_0982

2019-A00106-51 (Other Identifier)

Details and patient eligibility

About

The aim of this study is to assess if a bundle associating pressure support and positive end-expiratory pressure during spontaneous breathing trial and detection by T-piece of patients with high-risk of extubation failure can reduce the time to successful extubation in critically ill patients.

Enrollment: 98 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient 18 years old or more
• Intubated and ventilated in intensive care unit for more than 24 hours
• Patient ready for weaning evaluation
• Failure of a first T-piece SBT

Exclusion criteria

• Chronic neuromuscular disease
• Guillain-Barré Syndrome
• Central nervous system disease with consciousness disorder
• Tracheostomy
• Chronic disease with life expectancy less than 1 year
• Pregnancy, breast feeding
• Withholding life support regarding a reintubation
• Prisoner or patient interned in psychiatric hospital
• Guardianship
• Language barrier
• Lack of medical insurance
• Lack of the patient's consent (or of the next of kin where appropriate)
• Patient under an exclusion period after enrollment in another research study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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98 participants in 2 patient groups

Assisted strategy

Experimental group

Description:

Ability to be weaned is determined with pressure support and positive end-expiratory pressure.

Treatment:

Procedure: Assisted strategy

Non assisted strategy

Active Comparator group

Description:

Ability to be weaned is determined with T-piece.

Treatment:

Procedure: Non assisted strategy