Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation

Post Graduate Institute of Medical Education and Research, Chandigarh

Status: Unknown

Conditions: Ventilator Weaning; Respiration, Artificial

Treatments: Procedure: Spontaneous breathing trials; Procedure: Pressure support ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT00911378

weaning2009

Details and patient eligibility

About

This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.

Full description

Patients ventilated for more than 24 hours are randomized into two groups - one group of patients undergo gradual reduction of pressure support and in the other, T tube trials are used for weaning. The outcomes are compared in the two groups.

Enrollment: 130 estimated patients

Sex: All

Ages: 10 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mechanically ventilated patients for more than 24 hours
• Satisfies weaning criteria
• RSBI < 80
• Ratio of PaO2/FiO2 > 250
• Arterial partial pressure of oxygen more than 60 mm Hg and carbon dioxide less than 50 mm Hg

Exclusion criteria

• Systolic blood pressure of less than 100
• Arterial partial pressure of oxygen less than 60 mm Hg
• Poor sensorium

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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130 participants in 2 patient groups

Pressure support ventilation

Active Comparator group

Description:

Patients in this arm are weaned by gradual reduction of pressure support

Treatment:

Procedure: Pressure support ventilation

Spontaneous breathing trials

Active Comparator group

Description:

Patients in this arm are weaned by T piece trials

Treatment:

Procedure: Spontaneous breathing trials