Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques (MALTA)

Rennes University Hospital

Status: Completed

Conditions: Brain Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT01793714

2012-A00903-40

Details and patient eligibility

About

One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient 18 years and older
• Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery
• Patient able of accepting protocol information
• Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion criteria

• Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI
• Claustrophobic patient
• Patients who cannot cooperate for the fMRI
• Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty