Preterm Birth and Biomarkers for Cardiovascular Disease (BIO-PRETERM)

Uppsala University

Status: Completed

Conditions: Cardiovascular Diseases; Preterm Birth

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05693285

UU

Details and patient eligibility

About

Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of biomarkers for cardiovascular disease, to reveal potential pathophysiological mechanisms in common.

Full description

Women with spontaneous preterm birth in first pregnancy and a group of matched controls with spontaneous birth in normal time where invited to participate in the study. Participants were identified from the Biobank of Pregnant Women in Uppsala. Levels of cardiovascular biomarkers will be analyzed in plasma samples from the pregnancy and at a follow-up visit where investigators also collect information about other cardiovascular risk factors and lipid status.

Enrollment: 65 patients

Sex: Female

Ages: Under 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women identified as cases or controls

Exclusion criteria

• System inflammatory disease
• Smoking at the time of the pregnancy

Trial design

65 participants in 2 patient groups

Preterm birth

Description:

Women with spontaneous preterm birth in first pregnancy

Treatment:

Other: No intervention

Controls

Description:

Matched controls with spontaneous delivery in normal time in first pregnancy

Treatment:

Other: No intervention