Prevalence and Burden of Hepatitis D Virus Infection in China Through Preoperative Examination Test (Predict Study)

Nanjing Medical University

Status: Not yet enrolling

Conditions: Hepatitis D; RNA Virus Infections; Antibodies; Anti-D; Hepatitis B

Treatments: Diagnostic Test: HDV-Ab (IgG), HDV-RNA, RNA genotype

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT05394623

2021-8764

Details and patient eligibility

About

In China, there is no recommendation for Hepatitis D virus (HDV) screening, but the fact is estimated that one-third of the world's population of individuals with chronic Hepatitis B virus (HBV) infection live in China while we do not know the prevalence of co-infection of HBV/HDV in China. So far, no nationwide study has been undertaken to evaluate the epidemiology of hepatitis D, on the other hand, reports of HDV infection rate in different regions of China are not consistent because of the different detection methods and detection objects. Here, we plan to test HDV-Ab/RNA for 5000 HBsAg reactive samples from 10 major tertiary hospital and to know the prevalence and disease burden of HDV in China.

Enrollment: 5,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Positive HBV surface antigen (HBsAg)
2. Age 18 yeas and above

Exclusion criteria

1. Severe cardiac, renal, respiratory, hematological, or psychiatric illness.