Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients

Laval University

Status: Active, not recruiting

Conditions: Cardiac Surgery; Mechanical Ventilation After Surgery

Treatments: Diagnostic Test: Airway opening pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT07189026

2026-4399

Details and patient eligibility

About

Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure measurement could enhance individualized ventilatory strategies. Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion mismatch, increased respiratory effort, and postoperative pulmonary complications such as atelectasis and impaired gas exchange. Determining the prevalence and clinical relevance of significant airway opening pressure in post-cardiac surgery patients could contribute to more personalized respiratory strategies and improve postoperative care.

Enrollment: 196 estimated patients

Sex: All

Ages: 18+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (≥18 years)
• Undergoing elective coronary artery bypass grafting (CABG) or valve surgery, or combined procedures with expected postoperative mechanical ventilation

Exclusion criteria

- Patient receiving invasive mechanical ventilation prior to surgery

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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196 participants in 1 patient group

Post operative cardiac surgery

Other group

Treatment:

Diagnostic Test: Airway opening pressure