Prevalence and Effect of Lifestyle Modification on Clinical Outcomes and Cost-effectiveness Ratio for Sarcopenia

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Sarcopenia

Treatments: Behavioral: nutritional intervention; Behavioral: lifestyle modification project; Behavioral: resistance training program; Behavioral: control

Study type: Interventional

Funder types: Other

Identifiers

NCT02873676

PUMCH344801

Details and patient eligibility

About

The purposes of this study were to investigate the prevalence and risk factors for sarcopenia in Chinese adults and elderly, and evaluate the effect of Lifestyle Modification Project (LMP) on Clinical Outcomes, Quality of Life and Cost-effectiveness Ratio.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age>=18 year The participants must have basic cognitive function and communication Must be able to provide a written informed consent

Exclusion criteria

• age<18 year Concurrent severe cardiac disease, unstable diabetes mellitus,uncontrolled chronic disease,liver and renal failer, which may significantly interfere with study compliance.

Participants received any drugs or supplements known to influence effcet size,such as protein powder, calcium, or vitamin D before the 3 months preceding the study. Participants with electronic or mental device

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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200 participants in 4 patient groups, including a placebo group

nutritional intervention

Experimental group

Description:

This group received multi-dimensional intensive nutritional intervention for 3 month, which included whey (30g/d,plus three times every week ),vitamin D (1000IU) and omega-3 fatty acid (DHA 1200mg and EPA 800mg).

Treatment:

Behavioral: nutritional intervention

resistance training program

Experimental group

Description:

This group received resistance training program which is made up warm-up exercise, muscle strength training and relaxing.

Treatment:

Behavioral: resistance training program

lifestyle modification project

Experimental group

Description:

This group receive multi-dimensional intensive nutritional intervention and resistance training program.

Treatment:

Behavioral: lifestyle modification project

control

Placebo Comparator group

Description:

This group receive nutritional consulting,which involve dietary pattern modification and protein intake standardization.

Treatment:

Behavioral: control