Prevalence and Risk Factors for the Carriage of Bacteria and Clostridioid in Elderly Dependent Persons (PREMS)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Healthcare Associated Infection; Elderly

Treatments: Other: Feces sampling at inclusion (J0)

Study type: Observational

Funder types: Other

Identifiers

NCT04579094

LOCAL/2019/JO-01

Details and patient eligibility

About

Brief summary : Very few studies have evaluated the prevalence of multi-drug resistant (MDR), highly resistant emerging bacteria and Clostridioides difficile toxinogenic (CDt) in residents and in healthcare workers (HCW) in nursing home (NH). Most of study were conducted in acute care services and were limited to specific bacterial species.

Hypothesis : The carriage of MDR bacteria in resident may be a risk factor for an outbreak in NH or in healthcare facility.

Primary outcome: The objective of this study is to estimate the prevalence for carriage of MDR bacteria and CDt in residents in NH.

Secondary outcomes:

• Estimate the prevalence for carriage of MDR bacteria and CDt toxigenic in HCW in NH.
• Identify the risk factors for carriage of MDR bacteria and CDt in residents in nursing home
• Identify the risk factors for carriage of MDR bacteria and CDt in healthcare workers in NH
• Evaluate the presence of cross-transmission of MDR bacteria and CDt in one or several NH
• Evaluate the association between the presence of cross-transmission of MDR bacteria and CDt in a NH and the management of infection control
• Establishment a collection of stool samples

Enrollment: 492 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion criteria:
• Resident :

The resident must be a member or beneficiary of a health insurance. The resident is in permanent accommodation whose the date of admission is at least 1 month earlier on the day of collection.

• healthcare workers : The healthcare workers must be a member or beneficiary of a health insurance. The healthcare workers begin to work in nursing at least 1 month earlier on the day of collection.
• Exclusion criteria:
• Resident :

The resident refuses to participate.

o healthcare workers : The healthcare workers refuses to participate.

Trial design

492 participants in 2 patient groups

1/elderly dependent persons

Treatment:

Other: Feces sampling at inclusion (J0)

2/healthcare workers (HCW)

Treatment:

Other: Feces sampling at inclusion (J0)