Prevalence and Spectrum of Cancer Susceptibility Among Patients with Advanced Colorectal Polyps

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Colorectal Neoplasm

Treatments: Genetic: Multi-Cancer Cancer Panel

Study type: Observational

Funder types: Other

Identifiers

NCT04160832

18-2827.cc

Details and patient eligibility

About

The study is being conducted to determine the prevalence and risk factors for germline cancer susceptibility genetic mutations among patients with advanced colorectal polyps.

Enrollment: 200 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Provision to sign and date the consent form
• Stated willingness to comply with all study procedures and be available for the duration of the study
• Be a male or female aged 18-89
• Undergone colonoscopy
• At least one advanced colorectal polyp, defined as having any of the following:
• Any polyp ≥ 1cm (adenoma or serrated polyp)
• Any polyp with villous architecture
• Any polyp with high-grade dysplasia
• Sessile serrated polyps with any dysplasia
• Traditional serrated adenoma

Exclusion criteria

• Known hereditary cancer syndrome
• Personal history of inflammatory bowel disease
• Personal history of colorectal cancer
• Polyp histology or size unavailable or not documented