Prevalence of Acromegaly in a Diagnostic Consultation for Sleep Apnea Syndrome (ACROSAS)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Sleep Apnea Syndrome

Treatments: Other: Diagnosis of acromegaly

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02789696

13CHUG37

Details and patient eligibility

About

Prevalence of sleep apnea syndrome in patients with acromegaly is about 70%. It seems that comorbidities of arterial hypertension or type 2 diabetes are more severe in patients with acromegaly and sleep apnea syndrome. Besides sleep apnea syndrome associated to acromegaly gives rise to few symptoms, that explains it is under diagnosed. The mechanisms of the association are based on maxillofacial modifications linked to acromegaly, a thickening of soft tissues with deposits of glyco-aminoglycanes but probably also because of the associated obesity, of the potential existence of a goiter and a muscular dystrophy of the dilatative muscles of the pharynx.

At present, no study clearly documented prevalence of acromegaly in a diagnostic consultation for sleep apnea syndrome.

Full description

60 investigators will participate to this study. They will be chosen among those participating to the sleep observatory of the federation of pneumology (www.osfp.fr).

All participating pneumologists would have to fill in the questionnaire (co-morbidities, concomitant treatments, biological analysis) directly online and also clinical signs and symptoms of acromegaly. A blood test for the insulin-like growth factor (IGF-1) dosage will be systematically prescribed to the patient. Pneumologists will have to include all consecutive patients presenting with sleep apnea syndrome suspicion.

According to first IGF-1 results, patients may have to do a second blood test in a referenced laboratory to confirm the dosage.

Enrollment: 880 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Body mass index < 40 kg/m2
• Patient consulting for sleep breathing disorder
• Informed consent signed
• patient covered by french health insurance

Exclusion criteria

• Other sleep disorder already diagnosed
• Pregnant women
• Patients participating in an other study

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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880 participants in 1 patient group

Acromegaly

Other group

Description:

Diagnosis of acromegaly

Treatment:

Other: Diagnosis of acromegaly