Prevalence of Alpha-1 Antitrypsin Dysfunction in Pulmonary Emphysema (DysA)

Civil Hospices of Lyon

Status: Completed

Conditions: Pulmonary Emphysema

Treatments: Other: Blood sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT02382367

2013.835

Details and patient eligibility

About

The main objective of this trial is to evaluate the prevalence of alpha-1 antitrypsin quantitative and functional deficiency in an adult French population presenting with pulmonary emphysema. Phenotypic and genotypic studies will be carried whenever quantitative and/or functional deficiency will be displayed.

Enrollment: 190 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pulmonary emphysema highlighted by computed tomography
• Ratio Forced Expiratory Volume in 1 second (FEV1) / Vital Capacity (VC) < 70% measured by lung function test

Exclusion criteria

• Hepatic transplant
• Patient under legal protection
• Patient not benefiting from the French Health Insurance

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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190 participants in 1 patient group

Pulmonary emphysema

Experimental group

Description:

Blood tests (Alpha-1 antitrypsin protein measurement, elastase-inhibitory capacity of plasma measurement, phenotypic and genotypic studies)

Treatment:

Other: Blood sampling