Prevalence of Bacteriuria, Antibiotic Susceptibility, and Treatment Response in Symptomatic Benign Prostatic Hyperplasia (BPH)

Tribhuvan University Teaching Hospital, Institute Of Medicine.

Status: Completed

Conditions: Treatment Response to Antibiotics in Symptomatic Benign Prostate Hyperplasia; Bacteriuria in Symptomatic Benign Prostate Hyperplasia; Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia

Treatments: Drug: Antibiotic therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06520267

IRC/1694/019

Details and patient eligibility

About

The goal of this prospective observational study is to identify the common pathogens and antibiotic sensitivity pattern in urine samples of men with symptomatic BPH and to assess severity of LUTS in patients with symptomatic BPH using IPSS score before and after antibiotic therapy.

Full description

This was a hospital-based prospective observational study.

All patients with symptomatic BPH attending the Urology Out-Patient Department (OPD) of the study site were enrolled. Informed and written consent was obtained from all participants. Demographic data were recorded, and detailed histories were taken regarding the duration and symptoms of BPH, including incomplete bladder emptying, frequency, intermittency, urgency, weak stream, straining, nocturia, and relevant past history. IPSS scoring was conducted. A thorough clinical examination, including general physical, systemic, and digital rectal examination, was performed. During the rectal examination, the prostate was checked for nodules, softness, induration, or tenderness. Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile.

Enrollment: 131 patients

Sex: Male

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with symptomatic BPH.

Exclusion criteria

• Patients with indwelling catheters
• Recent antibiotic use
• Immunocompromised states (e.g., HIV, HCV)
• Uncontrolled diabetes mellitus (Hemoglobin A1c > 7%)
• Steroid therapy
• Those who declined to provide consent

Trial design

131 participants in 1 patient group

symptomatic BPH

Description:

All patients with symptomatic BPH attending the Urology Out-Patient Department (OPD) of the study site were enrolled. Informed and written consent was obtained from all participants. Demographic data were recorded, and detailed histories were taken regarding the duration and symptoms of BPH and relevant past history. IPSS scoring was conducted. A thorough clinical examination, including general physical, systemic, and digital rectal examination, was performed. During the rectal examination, the prostate was checked for nodules, softness, induration, or tenderness. Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile.

Treatment:

Drug: Antibiotic therapy