Prevalence of BK Viremia in Simultaneous Liver-Kidney Transplant

Methodist Health System

Status: Unknown

Conditions: Liver Transplant Infection; Kidney Transplant Infection; Polyomavirus Infections; BK Viremia

Treatments: Procedure: Simultaneous Liver-Kidney Transplant

Study type: Observational

Funder types: Other

Identifiers

NCT05224583

052.MTP.2021.D

Details and patient eligibility

About

The human BK polyomavirus is a significant risk factor for renal transplant dysfunction and allograft loss. The prevalence of BK viremia (BKV) following kidney transplantation is estimated to be 10-20%.

Full description

The human BK polyomavirus is a significant risk factor for renal transplant dysfunction and allograft loss. The prevalence of BK viremia (BKV) following kidney transplantation is estimated to be 10-20%. Immunosuppression reduction is the management cornerstone for BKV and has been shown to be effective at clearing the virus while maintaining graft function in both kidney alone and simultaneous kidney-pancreas transplant recipients. However, there is a lack of published data on the prevalence and outcomes in simultaneous liver-kidney (SLK) transplant recipients.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• SLK recipients transplanted at MDMC between 2015-2020

Exclusion criteria

• Below 18 years of age
• Patients who did not undergo SLK transplant at MDMC

Trial design

50 participants in 1 patient group

Simultaneous Liver-Kidney Transplant patients population at MDMC

Description:

Consecutive SLK transplant recipients who were transplanted at MDMC over a 6-year period (2015 to 2020).

Treatment:

Procedure: Simultaneous Liver-Kidney Transplant