Prevalence of BRCA in Patients With Ovarian Cancer

AGO Research

Status: Completed

Conditions: BRCA Status; Ovarian Cancer

Treatments: Genetic: Testing of BRCA status regarding germline and somatic mutation

Study type: Observational

Funder types: Industry

Identifiers

NCT02222883

AGO-TR 1

Details and patient eligibility

About

The aim of this prospective registration and translational research study is to evaluate the praevalence of BRCA regarding germline and somatic mutations.

Full description

Explorative analysis will be performed.

Enrollment: 530 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female ovarian cancer patients aged >= 18 years.
• Women with first diagnosis of epithelial ovarian cancer OR women diagnosed with platinum-sensitive recurrent ovarian cancer.
• Multiple platinum based prior therapies are allowed.

Exclusion criteria

• Non-epithelial ovarian malignancy.
• Platinum-resistant or refractory disease.
• Paraffin embedded tumor samples not available.

Trial design

530 participants in 2 patient groups

patients with primary diagnosis

Description:

patients with primary diagnosis of ovarian cancer for testing of BRCA status regarding germline and somatic mutation

Treatment:

Genetic: Testing of BRCA status regarding germline and somatic mutation

patients with platinum-sensitive recurrence

Description:

patients with platinum-sensitive recurrence of ovarian cancer for testing of BRCA status regarding germline and somatic mutation

Treatment:

Genetic: Testing of BRCA status regarding germline and somatic mutation