Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study (GPCBasedow)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Graves Disease

Treatments: Biological: serodiagnosis

Study type: Interventional

Funder types: Other

Identifiers

NCT02798965

AOL10-DR-DESAILLOUD

Details and patient eligibility

About

Lymphocytic thyroiditis is the most common autoimmune disease, usually affecting young women. Although the aetiology and pathogenesis remain obscure, the most widely accepted hypothesis is an interaction between a genetic predisposition and an environmental trigger factor such as viral infection. Parvovirus infections have been proposed as trigger factors for Hashimoto's thyroiditis and Graves' disease.

Enrollment: 52 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Graves' disease :patients treated for Graves' disease, the diagnosis date less than 4 months
• Control : patients cared for nodules or goiter

Exclusion criteria

• Patients undergoing immunosuppressive therapy including corticosteroids

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

52 participants in 2 patient groups

Control

Other group

Description:

patients with goiter or nodule

Treatment:

Biological: serodiagnosis

Graves' disease

Experimental group

Description:

patients with Graves' disease

Treatment:

Biological: serodiagnosis