Prevalence of COVID-19 Antibodies Kingman AZ

Kingman Regional Medical Center

Status: Completed

Conditions: Covid19

Treatments: Diagnostic Test: VITROS Anti-SARS-CoV-2 IgG test

Study type: Observational

Funder types: Other

Identifiers

NCT04533360

KRMC 0205

Details and patient eligibility

About

The COVID-19 disease outbreak is a historic event that has challenged medical systems in the United States. Currently, most reports of confirmed cases rely on the testing of symptomatic patients. These estimates of confirmed cases miss individuals who have recovered from infection, with mild or no symptoms, and individuals with symptoms who have not been tested due to the limited availability of tests. We are conducting serology testing within the community for SARS-CoV-2-specific antibodies through a serologic test could give insight into past COVID-19 infections within our community.

Full description

Adult participants aged 18 or greater will be recruited from the greater Kingman AZ area through social media, radio, newspaper, and a press release. Participants self-selected inclusion in the study by calling into a COVID-19 hotline and will be included in the sample data following self-report of absence of covid-19 symptoms. Participants will be scheduled for testing on the weeks of 09/28/2020 and 10/05/2020. Upon recruitment, participants will be asked to complete a demographic and behavioral survey, assessing socioeconomic status, interpersonal interactions, personal protective measures, and COVID-19 symptomology in the preceding two months. Two months after initial testing, all negative SARS-CoV-2-specific antibodies participants will be contacted for repeat testing and surveying.

SARS-CoV-2-specific antibodies will be tested using a lateral flow immunoassay with the VITROS Anti-SARS-CoV-2 IgG test (Ortho-Clinical Diagnostics, Inc.) under the Emergency Use Authorization (EUA) from the Food and Drug Administration (FDA). The diagnostic sensitivity of the immunoassay was 87.5% and specificity was 100%. The positive and negative predictive value with a prevalence of 5% in the community was 100% and 99.3% respectively. All data will be de-identified and stored in a password protected file only visible to study investigators. All positive results were called back to participants by the lead author.

Data obtained was then used to estimate the population prevalence of SARS-CoV-2-specific antibodies in the Kingman, Arizona population. Unweighted and weighted proportions of positive tests were calculated to match the 2018 census on sex, race, education, and income. Confidence intervals for unweighted data will be estimated using exact binomial models and for weighted and adjusted estimates using bootstrap methods. All data was analyzed using SPSS.

Enrollment: 566 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 18+
• Resident of Mohave County AZ

Exclusion criteria

• Children under 18yo
• Previous positive SARS-CoV2- Antibody Test
• Active symptoms of respiratory Illness

Trial design

566 participants in 4 patient groups

Community Cohort 1

Description:

1000 Participants from the community will be recruited to undergo serological testing for SARS-CoV2 Antibodies at time point 1.

Treatment:

Diagnostic Test: VITROS Anti-SARS-CoV-2 IgG test

Community Cohort 2

Description:

1000 Participants from the community will be recruited to undergo serological testing for SARS-CoV2 Antibodies at time point 2.

Treatment:

Diagnostic Test: VITROS Anti-SARS-CoV-2 IgG test

Healthcare Provider Cohort 1

Description:

500 hospital employees will be recruited to undergo serological testing for SARS-CoV2 Antibodies at time point 1.

Treatment:

Diagnostic Test: VITROS Anti-SARS-CoV-2 IgG test

Healthcare Provider Cohort 2

Description:

500 hospital employees will be recruited to undergo serological testing for SARS-CoV2 Antibodies at time point 2.

Treatment:

Diagnostic Test: VITROS Anti-SARS-CoV-2 IgG test