Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias (GAVE)

Mayo Clinic

Status: Enrolling

Conditions: Chronic Kidney Disease; Cirrhosis; Gastric Antral Vascular Ectasia

Treatments: Diagnostic Test: Gastric Emptying Breath Test

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT06306963

23-004669

Details and patient eligibility

About

The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this study, you will help us learn how often these symptoms occur and how they relate to stomach functioning.

Enrollment: 30 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients >18 years of age with endoscopic evidence of Gastric Antral Vascular Ectasia.
• Willingness to participate in the study
• Capacity to provide informed consent.
• No evidence of organic, systemic, or metabolic disease (e.g. diabetes mellitus) to explain the symptoms on routine investigations

Exclusion criteria

• Patients with transfusion dependent blood loss.
• Patients with severe decompensated liver disease.
• Patients with end stage renal disease.
• Presence of other diseases (structural or metabolic) which could interfere with interpretation of the study results.
• Pregnant or lactating women.
• Patients who have not had a CBC and differential blood draw completed within the last six months.
• Current heavy alcohol use.

Trial design

30 participants in 2 patient groups

Cirrhosis or Chronic Kidney Disease With Gastric Antral Vascular Ectasia

Description:

Patients with Gastric Antral Vascular Ectasia with cirrhosis or chronic kidney disease will undergo a gastric emptying breath test. This test is designed to show how quickly the stomach empties solids by measuring labeled carbon dioxide in a patient's breath.

Treatment:

Diagnostic Test: Gastric Emptying Breath Test

Cirrhosis or Chronic Kidney Disease Without Gastric Antral Vascular Ectasia

Description:

Patients without Gastric Antral Vascular Ectasia with cirrhosis or chronic kidney disease will undergo a gastric emptying breath test. This test is designed to show how quickly the stomach empties solids by measuring labeled carbon dioxide in a patient's breath.

Treatment:

Diagnostic Test: Gastric Emptying Breath Test