Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease

Chulalongkorn University

Status: Unknown

Conditions: Ischemic Stroke

Treatments: Genetic: DNA sequencing

Study type: Observational

Funder types: Other

Identifiers

NCT02720861

COA No.282/2015

Details and patient eligibility

About

To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.

Full description

This is an cross-sectional observational study in Chulalongkorn hospital, to determine the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were admitted in Chulalongkorn Hospital for acute ischemic stroke treatment.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Nationality in Thailand
• Age equal or more than 18 years
• Clinical and imaging diagnosis of acute ischemic stroke
• Patient consent to participate in the research

Exclusion criteria

• High risk for cardioembolic stroke by TOAST classification
• Contraindication for venipuncture
• Pregnancy or breast feeding patient
• History of head and neck radiation
• Down's syndrome
• Marfan syndrome
• Autoimmune disease such as SLE
• Ongoing malignancy or remission of malignancy less than 1year

Trial design

200 participants in 1 patient group

non embolic ischemic stroke

Description:

acute ischemic stroke from atherosclerosis or lacunar stroke

Treatment:

Genetic: DNA sequencing