Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation. (HINDIP)

Hospital Nacional Profesor Alejandro Posadas

Status: Enrolling

Conditions: Inflammation; Dengue; Hyponatremia

Treatments: Other: hyponatremia

Study type: Observational

Funder types: Other

Identifiers

NCT06109532

HINDIP162023

Details and patient eligibility

About

Prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Full description

Background Dengue infection is becoming more prevalent worldwide and is associated with systemic inflammation. Systemic Inflammation is associated with non-osmotic release of ADH.

Methods: Participants conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Enrollment: 530 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis confirmed by PCR, non structural protein 1 (NS1) antigen or IgM serology.

Plasma sodium at admission.

Exclusion criteria

• None

Trial design

530 participants in 3 patient groups

DENGUE INFECTED PATIENTS. YEAR 2016

Description:

We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and december 31, 2016. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Treatment:

Other: hyponatremia

DENGUE INFECTED PATIENTS. YEAR 2020

Description:

We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2020, and december 31, 2020. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Treatment:

Other: hyponatremia

DENGUE INFECTED PATIENTS. YEAR 2023

Description:

We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2023, and november 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Treatment:

Other: hyponatremia