Prevalence of Long-term Respiratory Complications of Severe SARS-CoV-2 Pneumonia - COVID-19

CHU de Reims

Status: Completed

Conditions: Severe SARS-CoV2 Pneumonia

Treatments: Other: Blood sample and data record

Study type: Interventional

Funder types: Other

Identifiers

NCT04376840

PO20066

Details and patient eligibility

About

Studies performed after coronavirus epidemics (severe acute respiratory syndrome coronavirus, SARS-CoV and Middle East respiratory syndrome coronavirus, MERS-CoV) have shown a long-term impact on respiratory morbidity, musculoskeletal and psycho-social repercussions.

Patients with SARS-CoV pneumonia had fibrotic pulmonary sequelae at 45 days (lower DLCO in 27.3% of cases and radiological lesions in 21.5% of cases). In the MERS-CoV pneumonia study, patients had radiological sequelae in 33% of cases and the 12-month evaluation showed persistence of radiological abnormalities in 23.7% of the cases despite an improvement in respiratory function.

Clinical presentation and therapeutic management of severe SARS-CoV-2 infection are in part similar to those induced by SARS-CoV and MERS-CoV. Long-term respiratory complications are therefore expected.

Full description

Objective is to evaluate prevalence of long-term respiratory complications after severe SARS-CoV2 pneumonia.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient
• Patient with with severe SARS-CoV2 pneumonia
• Patient consenting to participate to the study
• Patient enrolled in the national healthcare insurance program

Exclusion criteria

• Patient under 18 years

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

adults with severe SARS-CoV2 pneumonia

Experimental group

Description:

adult with severe SARS-CoV2 pneumonia

Treatment:

Other: Blood sample and data record