Prevalence of MAFLD Among Nurses and the Role of Intermittent Fasting

National University of Malaysia (UKM)

Status: Enrolling

Conditions: Fatty Liver Disease

Treatments: Behavioral: Intermittent Fasting

Study type: Interventional

Funder types: Other

Identifiers

NCT05880316

UKM/PPI/111/8/JEP-2023-276

Details and patient eligibility

About

This study consists of 2 parts:

Part 1: a cross-sectional study, looking at the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) among nurses in Hospital Canselor Tuanku Muhriz (HCTM).

Part 2: a randomized controlled trial of intermittent fasting with MAFLD subjects.

Full description

The investigators aim to screen at least 350 participants for fibroscan-detected fatty liver. Baseline anthropometric data will be taken. Questionnaires on dietary habits - Foof Frequency Questionnaire (FFQ) and exercise habits - International Physical Activity Questionnaire (IPAQ) will be done.

Approximately 100 participants who have fatty liver from Part 1 study, will be enrolled and randomized into Part 2. The intervention group will undergo intermittent fasting (3 fasting day:4 non-fasting days) while the control group will continue the usual standard care, for 8 weeks.

Measurements pre- and post-intervention include Fibroscan measurement, blood LiverFASt, anthropometric data, and exercise habit (IPAQ).

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• nurses at HCTM, 18 years and above

Exclusion criteria

• pregnancy
• previous bariatric surgery
• liver cirrhosis
• liver cancer
• steatogenic drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Intermittent Fasting Group

Experimental group

Description:

IF regime: 3 fasting day: 4 non-fasting day. On fasting day - allows to eat restricted calorie diet (up to 70% total daily calorie intake) for 8 hours.

Treatment:

Behavioral: Intermittent Fasting

Non-Fasting Group

No Intervention group

Description:

Usual care. Not allowed to fast