Prevalence of Malignant and Premalignant Lesions in the Head & Neck in Patients With Chronic Obstructive Pulmonary Disease

Hadassah Medical Center

Status: Unknown

Conditions: COPD, HEAD&NECK CANCER,SCREENING

Treatments: Other: Stroboscopic nasopharyngeal laryngoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02333812

0318-14-HMO-CTIL

Details and patient eligibility

About

Head and neck cancers usually occur in patients who have a history of long tobacco use. Chronic obstructive pulmonary disease (COPD) is a chronic progressive disease of the airways and lung parenchyma that is also associated with exposure to tobacco. COPD and head & neck cancer share a common environmental risk factor in cigarette smoke exposure. the investigators hypothesize that patients with chronic lung disease related to smoking have a higher risk to develop cancer in the head and neck.

The investigators designed a study to assess the prevalence of cancer and pre-cancer disease in the head & neck in patients with chronic lung disease. the investigators will examine patients with and without a history of smoking and chronic lung disease in order to determine the prevalence of head and neck cancer in the different groups. The patients who will be included in the study will undergo comprehensive evaluation of their lung function and voice performance.

This study is a joint effort of the Pulmonology Institute and the Department of Otolaryngology, Head & Neck Surgery in Israel and the Netherlands.

Enrollment: 250 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. group of adult COPD patients.
2. Adult patients with smoking history and no clinical manifestation of COPD who will be recruited form the institute of pulmonary medicine and the otolaryngology outpatient clinic.
3. Adult patients with lung disease unrelated to smoking, i.e. bronchial asthma who will be recruited from the institute of pulmonary medicine

Exclusion criteria

1. Patients with an acute disease or COPD exacerbation
2. Pregnant patients
3. Patients who were intubated ≤3 months prior to inclusion
4. Patients with a medical history of surgical intervention in the upper airway
5. Patients with a medical history of malignant disease in the upper airway
6. Patients who underwent radiotherapy of head and neck

Trial design

250 participants in 3 patient groups

copd patients

Description:

Adult patients with COPD

Treatment:

Other: Stroboscopic nasopharyngeal laryngoscopy

Other: Stroboscopic nasopharyngeal laryngoscopy

Other: Stroboscopic nasopharyngeal laryngoscopy

healthy smokers

Description:

Adult patients with smoking history and no clinical manifestation of COPD who will be recruited form the institute of pulmonary medicine and the otolaryngology outpatient clinic.

Treatment:

Other: Stroboscopic nasopharyngeal laryngoscopy

Other: Stroboscopic nasopharyngeal laryngoscopy

Other: Stroboscopic nasopharyngeal laryngoscopy

Adult patients with lung disease unrelated to smoking

Description:

Adult patients with lung disease unrelated to smoking

Treatment:

Other: Stroboscopic nasopharyngeal laryngoscopy

Other: Stroboscopic nasopharyngeal laryngoscopy

Other: Stroboscopic nasopharyngeal laryngoscopy