Prevalence of PE in ED Patients With Isolated Syncope (PEEPS)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Syncope

Treatments: Biological: Ddimer testing

Study type: Interventional

Funder types: Other

Identifiers

NCT03487237

K171102J

Details and patient eligibility

About

Syncope is a rapid onset, transient, loss of consciousness with a short duration. This symptom has been reported to be a specific presentation of patients with pulmonary embolism. However, the prevalence of pulmonary embolism in patients with syncope remains debated. This prospective cohort study will recruit patients presenting to the emergency department with a syncope, who will systematically undergo formal workup for pulmonary embolism. The main objective of this study is to assess the prevalence of pulmonary embolism in ED patients with syncope

Full description

Syncope is a rapid onset, transient, loss of consciousness with a short duration. This symptom has been reported to be a specific presentation of patients with pulmonary embolism. However, the prevalence of pulmonary embolism in patients with syncope remains debated. This prospective cohort study will recruit patients presenting to the emergency department with a syncope, who will systematically undergo formal workup for pulmonary embolism. The main objective of this study is to assess the prevalence of pulmonary embolism in ED patients with syncope

Enrollment: 459 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >= 18 years visiting the Emergency Department,
• history of syncope in the past 24 hours: loss of consciousness, rapid onset, short duration (<1 min), transient, with spontaneous and rapid recovery without post event confusion
• With or without prodromes
• Without any other obvious cause
• Informed written consent
• Affiliation to a social security system (AME Excepted)

Exclusion criteria

• Other criteria for PE suspicion : Acute onset of dyspnea Acute severe chest pain,

• Pregnancy
• Concurrent anticoagulation treatment
• Other obvious cause of syncope : Seizure, Stroke, Traumatic brain injury , toxic intake , Atrioventricular block type 3

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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459 participants in 1 patient group

All patient

Experimental group

Description:

Included patients will undergo a formal work up for pulmonary embolism: Ddimer testing, followed if positive by a computed tomography pulmonary angiogram or V/Q scan.

Treatment:

Biological: Ddimer testing