Prevalence of Primary Aldosteronism in Patients With Stroke

Changi General Hospital

Status: Completed

Conditions: Stroke; Primary Aldosteronism

Treatments: Diagnostic Test: Aldosterone renin ratio

Study type: Observational

Funder types: Other

Identifiers

NCT03789357

PA_CVA

Details and patient eligibility

About

Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.

Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.

Enrollment: 300 patients

Sex: All

Ages: 21 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 21-80 years
2. Admitted with acute cerebrovascular accident (CVA) or transient ischemic attack (TIA) to the ASU, CGH
3. Patients with both ischemic and hemorrhagic strokes

Exclusion criteria

a. Pregnant patients

Trial design

300 participants in 1 patient group

Single Arm

Description:

All patients admitted to the Acute Stroke Unit

Treatment:

Diagnostic Test: Aldosterone renin ratio