Prevalence of Replication of Human Herpes Virus 6 (HHV6) in Blood and Skin During Exanthemia, in Patients With Hemopathy. Is There a Correlation With the Etiology of the Exanthema? (REPLIPO)

Centre Hospitalier Universitaire, Amiens

Status: Unknown

Conditions: Exanthema; HHV6; Hemopathy

Treatments: Other: Measurement of the prevalence of the positivity of cutaneous HHV6 quantitative PCR in the cohort studied.

Study type: Observational

Funder types: Other

Identifiers

NCT03102905

PI2016_843_0017

Details and patient eligibility

About

To look for the replication of HHV6 by PCR in the skin, in these patients with haemopathies presenting an exanthema. This will make it possible to evaluate the prevalence of the positivity of this PCR in the skin. Then the investigator can investigate whether there is an association between the positivity of HHV6 PCR in the blood and / or skin and the viral etiology of the exanthema. If this association exists, it will make it possible to improve the diagnosis in the context of the exanthema and thus to improve the therapeutic management of these patients.

Enrollment: 45 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Supported for any type of hemopathy.
• Allograft, autografted or ungrafted haematopoietic stem cells
• Having presented an exanthema during hospitalization, for which a cutaneous biopsy had been performed
• Having had a blood test of the HHV6 virus by PCR at least within the previous 40 days or following the rash.
• Age greater than or equal to 18 years
• Patient informed of the protocol by post, not having refused within one month of sending the said courier.

Exclusion criteria

• Patient who refused the search.
• Patient whose HHV6 PCR in the blood was carried out at a distance of more than 40 days from the skin biopsy.